Endocrine Abstracts

Introduction: Adrenal oncocytoma (AO) and ganglioneuroma (GN) are rare causes of adrenal masses, corresponding usually to nonfunctional and benign tumors. However, 20% of the AO shows some elements of malignancy and 10–20% of them affect adrenal hormone production. GNs account for 0.3%-2% of adrenal incidentalomas, with punctate calcifications in CT imaging being highly suggestive. However, preoperative differential diagnosis remains challenging. Adrenal arterial emboliza...

Introduction: The usefulness of acute octreotide suppression test (OST) in the selection of patients with acromegaly for chronic somatostatin analogues (SA) treatment is still controversial.Aim: To investigate the predictive value of OST for long-term responsiveness to long-acting SA.Materials and methods: Retrospective study of 25 drug-naive patients (13 males) with active acromegaly, subjected to an OST (hourly serum GH concentra...

Introduction: Graves orbitopathy is the major extrathyroidal manifestation of Graves Disease (GD). The approach depends on its clinical activity and severity. Treatment and referral to specialized centers, with Endocrinology and Ophthalmology, has a strong impact on the prognosis of Graves’ Disease (GD) and GO.Cases report: We report four cases of DG with OG. Their characteristics and clinical evolution are shown in Table 1.<table boarder="1" ce...

Introduction: A third of pituitary adenomas are non-functioning. Classification depends on adenohypophyseal hormones expression and transcription factors.Aim: Characterize silent pituitary macroadenomas cases regarding their clinical data, treatment, histopathology and prognosis.Methods: We revised clinical process of patients followed in CHULC. Cases with non-access to clinical follow-up registries or exams were excluded.<p cl...

Introdution: Prolactinomas in men are rare and the majority are macroadenomas. Some studies suggest that these tumors in men have higher proliferative activity and aggressiveness indicating gender-specific differences in biological behavior. Dopamine agonists (DA) are considered first-line therapy.Material/methods: Retrospective analysis of male patients diagnosed with prolactinoma between 2005 and 2016. Age at presentation, clinical, hormonal and image ...

Introduction: somatostatin analogs (SSA) are largely prescribed in acromegalic patients, whether as adjuvant or primary therapy. Response is variable and seems dependent of histological subtype. Intensity T2 signal in MRI has been related to granulation patern and accordingly with response to SSA.Objective: To evaluate whether T2 MRI signal is correlated with effectiveness of SSAMaterial and methods: Retrospective analysis of acrom...

Introduction: Medical therapy of acromegaly is indicated in patients who failed to achieve remission after surgery, with contraindication or refusal for surgical therapy or following radiotherapy in order to bridge the interval until complete remission.Objective: Evaluate the medical therapy – somatostatin analogs (SSA), dopamine agonist (DAs) and GH receptor-antagonist (Pegvisomant) – in acromegalic patients followed from 1988–2011.<p...

Medullary thyroid carcinoma (MTC) is a rare tumor of C cell origin, that may be sporadic or familial. Diagnosis is often delayed and its course variable.Objectives: Evaluation of clinical characteristics and outcome of patients diagnosed with MTC.Methods: Retrospective analysis of clinical records of patients with MTC between 2005 and 2016. We considered undetectable serum calcitonin as criteria of cure.Resul...

Introduction: Pituitary tumours are considered benign, however some exhibit an aggressive behavior. Defining a timely treatment is challenging due to absence of accurate prognostic predictors.Objective: To evaluate radiological and histopathological features of aggressive pituitary tumours.Methods: Multicenter and retrospective study. Criteria for aggressiveness were: invasion to sphenoid and/or cavernous sinus; growth progression ...